Paper Highlight: https://link.springer.com/article/10.1186/s13293-024-00660-w
- A number of our undergraduate and master’s students co-author papers. Check out individual people for their contributions
2024
Alexander, S.N., Reed, O.A., Burton, M.D. Spinal Cord Microglia Drive Sex Differences in Ethanol-induced Allodynia. (in press, Brain, Behavior, and Immunity 2024)
Lenert, M.E., Debner, E.K., Burton M.D. Sensory neuron LKB1 mediates ovarian and reproductive function. (in press, Scientific Reports 2024)
Alexander, S. N.#, Green, A. R.#, Debner, E. K.#, Abdelhadi, H.M.K., Ramos Freitas, L. E., Szabo-Pardi, T.A., Burton, M. D. The Influence of Sex on Neuroimmune Communication, Pain, and Physiology. (in press Biology of Sex Differences) #co-first authors.
12/15-Lipoxygenases mediate neuropathic-like pain hypersensitivity in female mice. bioRvix [Preprint]. 2024 Apr 8:2024.04.04.588153. doi: 10.1101/2024.04.04.588153.
Shebindu A., Kaveti, D., Umutoni L., Kirk, G., Burton M.D., Jones, C.J. A Programmable Microfluidic Platform to Monitor Calcium Dynamics in Microglia during Inflammation. Research Square [Preprint]. 2023 Dec 28:rs.3.rs-3750595. doi: 10.21203/rs.3.rs-3750595/v1. (in press; Nature Microsystems & Nanoengineering)
Rivera-Garcia, L.G., Francis-Malave, A.M., Castillo, Z.W., Uong, C.D., Wilson, T.D., Ferchmin, P.A., Eterovic, V, Burton, M.D., Carrasquillo, Y. Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco cembranoid in a mouse model of inflammatory pain. Journal of inflammation 2024 Jan 24;21(1):2. doi: 10.1186/s12950-023-00373-8.
2023
Singh, S.*, Guindon, J.*, Mody, P. H., Arandia, G. Kopel, J., Chilakapati, S., Adogwa, O., Neugebauer, V., Burton, M.D. Pain and aging: A unique challenge in neuroinflammation and behavior. Mol Pain. 2023 Sep 8:17448069231203090. doi: 10.1177/17448069231203090. Online ahead of print. PMID: 37684099
Lenert, M.E. and Burton M.D. Sensory neuron LKB1 mediates ovarian and reproductive function. bioRxiv. 2023 2023 Mar 28:2023.03.28.534533. doi: 10.1101/2023.03.28.534533. Preprint. PMID: 37034663
Sankaranarayanan, I., Tavares-Ferreira, D., Mwirigi, J.M., Mejia, G.L., Burton, M.D., Price, T.J. Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice. Journal of Neuroinflammation. 2023 Feb 11;20(1):32. doi:10.1186/s12974-023-02719-8.
Kume, M., Ahmad, A., Shiers, S., Burton, M.D., DeFea, K.A., Vagner, J., Dussor, G., Boitano, S., Price, T.J. C781, a b-arrestin biased antagonist at PAR2, displays efficacy against protease-induced pain in mice. J Pain. 2023 Apr; 24(4):605-616. doi: 10.1016/j.jpain.2022.11.006.
2022
Dos Santos, N.L., Lenert, M.E., Castillo, Z.W., Mody, P.H., Thompson, L.T., Burton, M.D. Postoperative pain drives differential neuroimmune phenotypes across age and sex. Neurobiol Aging. 2022 Nov 23:S0197-4580(22)00240-8. doi: 10.1016/j.neurobiolaging.2022.09.008. Online ahead of print.
Alexander SN, Jeong HS, Szabo-Pardi TA, Burton MD. Sex-specific differences in alcohol-induced pain sensitization. Neuropharmacology. 2022 Nov 29;225:109354. doi: 10.1016/j.neuropharm.2022.109354.
Tierney, J.A., Uong, C.D., Lenert, M.E., Williams, M.+, Burton, M.D. High-fat Diet causes mechanical allodynia in the absence of previous injury or diabetic pathology. Scientific Reports. 2022 Sep 1:12(1). Doi 10.1038/s41598-022-18281-x
Lenert, M.E., Szabo-Pardi, T.A., Burton, M.D. Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain. Molecular Pain. 2022 June 17 doi: 10.1177/17448069221110691. Online ahead of print.
Chilakapati, S., Burton, M.D., Adogwa, O. Preoperative Polypharmacy in Geriatric Patients is associated with increased 90-day All-Cause hospital readmission after surgery for adult Spinal Deformity Patients. World Neurosurgery. 2022 May doi: 10.1016/j.wneu.2022.04.137. Online ahead of print.
Ray, P.R., Shiers, S., Caruso, J.P., Tavares-Fereira, D., Sankaranarayanan, I., Uhelsk, M.L., Li, Y., North, R.Y., Tatsui, C., Dussor, G., Burton, M.D., Dougherty, P.M., Price, T.J. RNA profiling of human dorsal root ganglia reveals sex-differences in mechanisms promoting neuropathic pain. Brain. 2022 Jul 22:awac266. Doi: 10.1093/brain/awacc266
Garner, K.M. and Burton, M.D. The sex-specific role of sensory neurons LKB1 on metabolic stress-induced mechanical hypersensitivity and mitochondrial respiration. (Am J Physiol Regul Integr Comp Physiol. 2022 May 3. doi: 10.1152/ajpregu.00279.2021. Online ahead of print)
Lenert, M.E., Gomez, R.+, Lane, B.T.+, Daily, DL, Geasland, K.G., Crofford, L.J., Sluka, K.A., Merriwether, E.N., Burton, M.D. Translating outcomes from the clinical setting to preclinical models: chronic pain and functionality in chronic musculoskeletal pain. (BioRxiv/Pain Medicine. 2022 Mar 24:pnac047. doi: 10.1093/pm/pnac047. Online ahead of print. PMID: 35325207)
Tavares-Ferreira D, Shiers S, Ray PR, Wangzhou A, Jeevakumar V, Sankaranarayanan I, Cervantes AM, Reese JC, Chamessian A, Copits BA, Dougherty PM, Gereau RW 4th,Burton MD, Dussor G, Price TJ. Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors.Sci Transl Med. 2022 Feb 16;14(632):eabj8186. doi: 10.1126/scitranslmed.abj8186. Epub 2022 Feb 16.PMID: 35171654
Hall, BE, Macdonald, E, Cassidy, M, Yun, S, Sapio MR, Ray P, Doty M, Nara P, Burton MD, Shiers, S, Ray-Chaudhury, Mannes AJ, Price TJ, Iadarola MJ, Kulkarni AB. Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss. Scientific Reports. 2022 Mar 18;12(1):4729. doi: 0.1038/s41598-022-08100-8.
2021
Castillo, ZW & Burton, M.D. Utilizing multiphoton imaging and integrative clearing to reveal sex differences in neuroimmune interactions after nerve injury. Neural Regeneration Research. online ahead of Print Dec 2021
Lenert, M.E. & Burton, M.D. Acute effects of a high-fat diet on estrous cycling and body weight of intact female mice. Neuropsychopharmacology. 2021 epub ahead of print
Szabo-Pardi, T.A., Barron, L.R., Lenert, M.E., Burton, M.D. Sensory Neuron TLR4 mediates the development of nerve-injury induced mechanical hypersensitivity in female mice. Brain, Behavior, and Immunity. 2021 June epub ahead of print
Moarefian, M., Davalos, R.V., Burton, M.D., Jones C.N., Electrotaxis-on-Chip to Quantify Neutrophil Migration Towards Electrochemical Gradients. Frontiers in Immunology. 2021 Aug6;12:674727.doi:10.3389/fimmu.2021.674727.
Lenert, M.E., Avona, A., Garner, K.M., Barron, L.R., Burton, M.D. Sensory neurons, neuroimmunity, and pain modulation by sex hormones. Endocrinology. 2021 May 28:bqab109. doi: 10.1210/endocr/bqab109. Online ahead of print.PMID: 34049389
Agalave, N.M.*, Mody, P.H.*, Szabo-Pardi, T.A., Jeong, H.S.+, Burton, M.D. Neuroimmune consequences of eIF4E phosphorylation on chemotherapy-induced peripheral neuropathy. Frontiers in Immunology (accepted, in press) (March 2021) Front. Immunol. | doi: 10.3389/fimmu.2021.642420. *co-first author https://www.frontiersin.org/articles/10.3389/fimmu.2021.642420/abstract
Lenert, M.E., Chaparro, M.M., Burton, M.D. Homeostatic Regulation of Estrus Cycle of Young Female Mice on Western Diet. Journal of the Endocrine Society (JES) (accepted), epub ahead of print online (February 2021) https://doi.org/10.1210/jendso/bvab010
Szabo-Pardi, T.A.*, Syed, U.*, Castillo, Z.W., Burton M.D. Use of Integrated Optical Clearing and 2-Photon Imaging to Investigate Sex Differences in Neuroimmune Interactions after Peripheral Nerve Injury. Frontiers Cell and Developmental Biology, online ahead of Print Janurary 2021. * co-first author
2020
Jia, L., Lee, S., Tierney, J.A., Elmquist, J.K., Burton, M.D.*, Gautron, L.* TLR4 signaling selectively and directly promotes CGRP release from vagal afferents. eNeuro 14 December 2020, ENEURO.0254-20.2020; DOI: https://doi.org/10.1523/ENEURO.0254-20.2020*co-corresponding author
Mody, P.H., Santos, N.L., Lenert, M.E., Barron, L.R., Nottingham, B.L, Burton, M.D. The role of cap-dependent translation in aged-related changes in neuroimmunity and affective behaviors. Neurobiology of Aging 2020 Nov 13;98:173-184. doi: 10.1016/j.neurobiolaging.2020.10.014. Online ahead of print.
Szabo-Pardi TA, Agalave NM, Burton MD. The role of microglia versus peripheral macrophages in maladaptive plasticity after nerve injury. Neural Regen Res. 2021 Jun;16(6):1202-1203. doi: 10.4103/1673-5374.300438. PMID: 33269776.
Grace PM, Tawfik VL, Svensson CI, Burton MD, Loggia ML, Hutchinson MR. The Neuroimmunology of Chronic Pain: From Rodents to Humans. J Neurosci . 2020 Nov 24;JN-SY-1650-20. doi: 10.1523/JNEUROSCI.1650-20.2020. Online ahead of print.
Segarra VA, Primus C, Unguez GA, Edwards A, Etson C, Flores SC, Fry C, Guillory AN, Ingram SL, Lawson M, McGee R, Paxson S, Phelan L, Suggs K, Vega LR, Vuong E, Havran JC, Leon A, Burton MD, Lujan JL, Ramirez-Alvarado M. Scientific societies fostering inclusivity through speaker diversity in annual meeting programming: a call to action. Mol Biol Cell. 2020 Nov 1;31(23):2495-2501. doi: 10.1091/mbc.E20-06-0381.
Merriwether EN*, Agalave NM, Dailey DL, Rakel BA, Kolker SJ, Lenert ME, Spagnola WH, Lu Y, Geasland KM, Allen LH, Burton MD*, Sluka KA*. IL-5 mediates monocyte phenotype and pain outcomes in fibromyalgia. Pain. 2020 Sep 24. doi: 10.1097/j.pain.0000000000002089. Online ahead of print. *co-corresponding author
Rudjito R, Agalave NM, Farinotti AB, Lundbäck P, Szabo-Pardi T, Price TJ, Harris HE, Burton MD*, Svensson CI*. Sex- and cell-dependent contribution of peripheral HMGB1 and TLR4 in arthritis-induced pain. Pain. 2020 Aug 6. doi: 10.1097/j.pain.0000000000002034. Epub ahead of print. PMID: 32796317. *co-corresponding author
Agalave NM, Rudjito R, Farinotti AB, Khoonsari PE, Sandor K, Nomura Y, Szabo-Pardi TA, Urbina CM, Palada V, Price TJ, Harris HE, Burton MD*, Kultima K*, Svensson CI*. Sex-dependent role of microglia in disulfide HMGB1-mediated mechanical hypersensitivity. Pain. 2020 Aug 5. Epub ahead of print. PMID: 32773600. *co-corresponding author
Mody PH, Dos Santos NL, Barron LR, Price TJ, Burton MD. eIF4E phosphorylation modulates pain and neuroinflammation in the aged [published online ahead of print, 2020 Jul 1]. Geroscience. 2020;10.1007/s11357-020-00220-1. doi:10.1007/s11357-020-00220-1
Ray PR, Wangzhou A, Ghneim N, Yousuf MS, Paige C, Tavares-Ferreira D, Mwirigi JM, Shiers S, Sankaranarayanan I, McFarland AJ, Neerukonda SV, Davidson S, Dussor G, Burton MD, Price TJ. A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction. Brain Behavior & Immunity. 2020 Jun 1:S0889-1591(20)30670-X. doi: 10.1016/j.bbi.2020.05.078. Epub ahead of print. PMID: 32497778; PMCID: PMC7263237.
Hassler SN, Kume M, Mwirigi JM, Ahmad A, Shiers S, Wangzhou A, Ray PR, Belugin SN, Naik DK, Burton MD, Vagner J, Boitano S, Akopian AN, Dussor G, Price TJ. The cellular basis of protease-activated receptor 2-evoked mechanical and affective pain. JCI Insight. 2020 Jun 4;5(11):e137393. doi: 10.1172/jci.insight.137393. PMID: 32352932; PMCID: PMC7308051.
Agalave NM, Lane BT, Mody PH, Szabo-Pardi TA, Burton MD. Isolation, culture, and downstream characterization of primary microglia and astrocytes from adult rodent brain and spinal cord. Journal of Neuroscience Methods. 2020 Apr 19;340:108742. doi: 10.1016/j.jneumeth.2020.108742.
Milligan, A.L., Szabo-Pardi, T.A., Burton, M.D. Cannabinoid Receptor type 1 and it’s role as an analgesic: An opioid alternative? Journal of Dual Diagnosis 2020 Jan-Mar;16(1):106-119. doi: 10.1080/15504263.2019.1668100.
Ruhl CR, Pasko BL, Khan HS, Kindt LM, Stamm CE, Franco LH, Hsia CC, Zhou M, Davis CR, Qin T, Gautron L, Burton MD, Mejia GL, Naik DK, Dussor G, Price TJ, Shiloh MU. Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough. Cell. 2020 Apr 16;181(2):293-305.e11. doi: 10.1016/j.cell.2020.02.026. Epub 2020 Mar 5. PMID: 32142653; PMCID: PMC7102531.
Hassler SN, Kume M, Mwirigi J, Ahmad A, Shiers S, Wangzhou A, Ray P, Belugin SN, Naik DK, Burton MD, Vagner J, Boitano S, Akopian AN, Dussor G, Price TJ. The cellular basis of protease activated receptor type 2 (PAR2) evoked mechanical and affective pain. JCI Insight. 2020 Apr 30. pii: 137393. doi: 10.1172/jci.insight.137393.
2019
Sparkman, N.L., Buchanan, J.B., Dos Santos, N.L., Johnson, R.W., Burton, M.D. Aging sensitizes male mice to cognitive dysfunction induced by central HIV-1 gp120. Experimental Gerontology 2019 Oct 15;126:110694. doi: 10.1016/j.exger.2019.110694.
Pardi, TA, Agalave, NM, Andrew, TA, Burton, MD. In vivo Two-Color 2-Photon Imaging of Genetically-Tagged Reporter Cells in the Skin. Journal of Visualized Experiments (JoVE). 2019 April. [Epub ahead of production].
Inyang, K, Burton MD, Szabo-Pardi TA, Wentworth E, McDougal, TA, Ramirez, ED, Pradhan, G, Dussor, G, and Price TJ. Indirect AMPK activators prevent incision-induced hyperalgesia and block hyperalgesic priming while positive allosteric modulators only block priming in mice. The Journal of Pharmacology and Experimental Therapeutics (JPET). 2019 Jul 19. pii: jpet.119.258400. doi: 10.1124/jpet.119.258400. [Epub ahead of print] PubMed PMID:31324647.
Avona A, Burgos-Vega C, Burton MD, Akopian A, Price TJ, Dussor G. Dural calcitonin gene-related peptide produces female-specific responses in rodent migraine models. J Neurosci. 2019 Apr 8. pii: 0364-19. doi: 10.1523/JNEUROSCI.0364-19.2019. [Epub ahead of print] PubMed PMID: 30962278.
Leon Mercado L, Caron A, Wang Y, Burton MD, Gautron L. Identification of leptin receptor-expressing cells in the nodose ganglion of male mice. Endocrinology. 2019 Mar 25. pii: en.2019-00021. doi: 10.1210/en.2019-00021. [Epub ahead of print]
2018 and before
Moy JK, Szabo-Pardi T, Tillu DV, Megat S, Pradhan G, Kume M, Asiedu MN, Burton MD, Dussor G, Price TJ. Temporal and sex differences in the role of BDNF/TrkB signaling in hyperalgesic priming in mice and rats. Neurobiol Pain. 2018 Oct 19;5:100024. doi: 10.1016/j.ynpai.2018.10.001.
Inyang KE, Szabo-Pardi T, Wentworth E, McDougal TA, Dussor G, Burton MD*, Price TJ*. The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice. Pharmacol Res. 2018 Nov 1;139:1-16. doi: 10.1016/j.phrs.2018.10.027. [Epub ahead of print] * co-corresponding authors
Garner KM, Amin R, Johnson RW, Scarlett EJ, Burton, MD. Microglia priming by interleukin-6 signaling is enhanced in aged mice. Journal of Neuroimmunology. 2018 September 10; (online). doi:10.1016/j.jneuroim.20185.09.002
Udit S, Burton MD, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L. Na(v)1.8 neurons are involved in limiting acute phase responses to dietary fat. Mol Metab. 2017 Oct;6(10):1081-1091. doi:10.1016/j.molmet.2017.07.012.
Burton MD, Tillu DV, Mazhar K, Mejia GL, Asiedu MN, Inyang K, Hughes T, Lian B, Dussor G, Price TJ. Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice. Neuroscience. 2017 Sep 17;359:119-129. doi:10.1016/j.neuroscience.
Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ. The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain. J Neurosci. 2017 Aug 2;37(31):7481-7499. doi:10.1523/JNEUROSCI.0220-17.2017.
Burton MD, Rytych JL, Amin R, Johnson RW. Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice. Rejuvenation Res. 2016 Aug;19(4):286-92. doi: 10.1089/rej.2015.1708.
Elmore MR, Burton MD, Conrad MS, Rytych JL, Van Alstine WG, Johnson RW. Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. J Neurosci. 2014 Feb 5;34(6):2120-9. doi: 10.1523/JNEUROSCI.2180-13.2014.
Gautron L, Rutkowski JM, Burton MD, Wei W, Wan Y, Elmquist JK. Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen. J Comp Neurol. 2013 Nov;521(16):3741-67. doi: 10.1002/cne.23376.
Conrad MS, Elmore MR, Burton MD, Rytych JL, Johnson RW. Early-life viral infection causes neuroinflammation, cognitive deficits, and changes in neurogenesis in the neonatal piglet. Brain, Behavior, and Immunity 2013 32, e8
Burton MD, Rytych JL, Freund GG, Johnson RW. Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged mice. Brain Behav Immun. 2013 May;30:66-72. doi: 10.1016/j.bbi.2013.01.002.
Rytych JL, Elmore MR, Burton MD, Conrad MS, Donovan SM, Dilger RN, Johnson RW. Early life iron deficiency impairs spatial cognition in neonatal piglets. J Nutr. 2012 Nov;142(11):2050-6. doi: 10.3945/jn.112.165522.
Burton MD, Johnson RW. Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning. Brain Behav Immun. 2012 Jul;26(5):732-8. doi: 10.1016/j.bbi.2011.10.008.
Burton MD, Sparkman NL, Johnson RW. Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior. J Neuroinflammation. 2011 May 19;8:54. doi:10.1186/1742-2094-8-54
Sparkman NL, Burton MD, Heyen JR, Beverly JL, Johnson RW. Mice deficient in interleukin-6 are refractory to lipopolysaccharide-induced disruption in working memory. Brain, Behavior, and Immunity 2006; 19 (4), e66-e67