Mengxiao Yu

Education Background

Postdoc in Chemistry,  The University of Texas at Dallas, 2009-present.

Ph.D. Laboratory of Advanced Materials, Fudan University, Shanghai, China, 2009.

B.S.  Department of Chemistry, Beijing Normal University, Beijing, China, 2004.

Research Area

Intracellular Labeling, Drug Delivery and Kidney functional Imaging.

Honors and Awards

Best Poster in Biomaterials and Tissue, UT Metroplex Day, 2010.

Selected Publications

  1. J. Xu,M. Yu, P. Carter A, E. Hernandez, A. Dang, P. Kapur, J. T. Hsieh, J. Zheng. “In Vivo X-ray Imaging of Transport of Renal Clearable Gold Nanoparticles in the Kidneys”,Angew. Chem. Int. Ed.,2017, DOI: 10.1002/anie.201707819 (online) (Highlighted as VIP)
  2. Bujie Du, Xingya Jiang, Anindita Das, Qinhan Zhou,Mengxiao Yu, Rongchao Jin, Jie Zheng, “Glomerular barrier be haves as an atomically precise bandpass filter in a sub-nanometre regime”Nature nanotechnology, 2017 DOI: 10.1038/NNANO.2017.170 (online)
  3. Yu, M., Zhou, C., Liu, L., Zhang, S., Sun, S., Hankins, J.D., Sun, X. and Zheng, J., 2017. “Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects.”Angew. Chem. Int. Ed., 56, pp.4314-4319
  4. Jing Xu, Chuanqi Peng,Mengxiao Yuand Jie Zheng. “Renal clearable noble metal nanoparticles: photoluminescence, elimination, and biomedical applications.” WIREs Nanomed Nanobiotechnol2017. doi: 10.1002/wnan.1453)
  5. Chuanqi Peng, Xiaofei Gao, Jing Xu, Bujie Du, Xuhui Ning, Shaoheng Tang, Robert M. Bachoo,Mengxiao Yu, Woo Ping Ge and Jie Zheng “Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles.”Nano Research, 2017 4, 1366-1376
  6. Shaoheng Tang, Chuanqi Peng, Jing Xu, Bujie Du, Qinxiao Wang,Rodrigo D. Vinluan,Mengxiao Yu, Moon J. Kim and Jie Zheng. “Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density.” Angew. Chem. Int. Ed., 2016, 55, 16039-16043
  7. 16.B. Liu, P.N. Duchesne,M.X. Yu, X.Y. Jiang, X.H. Ning, P. Zhang, J. Zheng. “Luminescent Gold Nanoparticles with Size-independent Emissions”, Angew. Chem. Int. Ed., 2016. 55, 8894-8898 
  8. M. X. Yu, J. C. Zhou, B. J. Du, X. H. Ning, C. Authement, L. Gandee, P. Kapur, J. T. Hsieh, J. Zheng. “Noninvasive Staging of Kidney Dysfunction Enabled by Renal Clearable Luminescent Gold Nanoparticles”,Angew. Chem. Int. Ed., 55, 2787-2791 (2016) (Highlighted as VIP).
  9. 14.M. X. Yu, J. B. Liu, X. H. Ning, J. Zheng*. “High-contrast Noninvasive Imaging of Kidney Clearance Kinetics Enabled by Renal Clearable Nanofluorophores”. Angew. Chem. Int. Ed. 54, 15434-15438 (2015).
  10. M. X. Yu, J. Zheng*. “Clearance Pathways and Tumor Targeting of Imaging Nanoparticles”.ACS Nano, 2015, 9, 6655–6674 (2015) (Invited review article, Highlighted as one of the “top 5 most read articles” of ACS Nano in July 2015).
  11. R. D. Vinluan III, M. X. Yu, M. Gannaway, J. Sullins, J. Xu, Jie Zheng*. “Labeling Monomeric Insulin with Renal-Clearable Luminescent Gold Nanoparticles”.Bioconjugate Chem., DOI: 10.1021/acs.bioconjchem.5b00490 (2015).
  12. J. B. Liu,M. X. Yu, C. Zhou, J. Zheng*. “Renal Clearable Inorganic Nanoparticles: A New Frontier of Bionanotechnology”.Mater. Today 16, 477-486 (2013).
  13. J.B. Liu,M.X. Yu, X. Ning, C. Zhou, S.Y. Yang, and J. Zheng*, “PEGylation and Zwitterionization: Pros and Cons in Renal Clearance and Tumor Targeting of Near-IR-Emitting Gold Nanoparticles”,Angew. Chem. Int. Ed.52, 12572-12576 (2013) (Highlighted as VIP)
  14. J. Liu,M. Yu, C. Zhou, S. Yang, X. Ning, and J. Zheng, “Passive Tumor Targeting of Renal Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance”,J. Am. Chem. Soc., 2013, 135, 4978-4981 (2013).
  15. J. Zheng*, C. Zhou,M. X. Yu, J. B. Liu. “Different sized luminescent gold nanoparticles”.Nanoscale 4, 4073-4083 (2012) (Highlighted as one of the “top 10 most accessed articles” of Nanoscale in June and July 2012).
  16. 7. Yu,† C. Zhou,† J. Liu, J. D. Hankins, J. Zheng, “Luminescent Gold Nanoparticles with pH De-pendent Membrane Adsorption”,J. Am. Chem. Soc., 133, 11014-11017 (2011).
  17. C. Y. Li,M. X. Yu, Y. Sun, Y. Q. Wu, C. H. Huang, F. Y. Li*. “A Nonemissive Iridium(III) Complex That Specifically Lights-Up the Nuclei of Living Cells”.J. Am. Chem. Soc. 133, 11231-11239 (2011) (Highlighted by Chemical and Engineering News).
  18. 5. C. Zhou, C. Sun, X. Yu, Y. P. Qin, J. G. Wang, M. Kim, J. Zheng*. “Luminescent Gold Nanoparticles with Mixed Valence States Generated from Dissociation of Polymeric Au(I) Thiolates”.J. Phys. Chem. C 114, 7727-7732 (2010).
  19. 4.X. Yu, F.Y. Li, Z.G. Chen, H. Hu, C. Zhan, H. Yang, C.H. Huang, “Laser Scanning Up-conversion Luminescence Microscopy for Imaging Cells Labeled with Rare-earth Nanophospors”,Anal. Chem., 81, 930–935 (2009).
  20. 3.X. Yu, M. Shi, Z.G. Chen, F.Y. Li, X.X. Li, Y.H. Gao, J. Xu, H. Yang, Z.G. Zhou, T. Yi, C.H. Huang, “Highly Sensitive and Fast Responsive Fluorescence Turn-on Chemodosimeter for Cu2+and its Application in Live Cell Imaging”, Chem. Eur. J.14, 6892–6900 (2008).
  21. 2.X. Yu, Q. Zhao, L.X. Shi, F.Y. Li, Z.G. Zhou, H. Yang, T. Yi, C.H. Huang, “Cationic Iridium(III) Complexes for Phosphorescence Staining in the Cytoplasm of Living Cells”,Chem. Comm., 2115–2117 (2008).
  22. 1. M. Zhang,X. Yu, F.Y. Li, M.W. Zhu, M.Y. Li, Y.H. Gao, L. Li, Z.Q. Liu, J.P. Zhang, D.Q. Zhang, T. Yi, C.H. Huang,“A Highly Selective Fluorescence Turn-on Sensor for Cysteine/Homocysteine and its Application in Bioimaging”, J. Am. Chem. Soc., 129, 10322–10323 (2007).