Scalable Electrode Technology for High Resolution Chronic Recording of Brain

The goal of this project is to develop and demonstrate ultra-small microelectrode arrays leveraging amorphous silicon carbide for rodent and non-human primate applications. This NIH funded effort R01 NS104344 is a collaborative multi-PI project spanning UT-Dallas Professors Stuart Cogan (PI) and Joseph Pancrazio (co-PI), Northwestern University Professor Lee Miller (co-PI), and Blackrock Microtechnologies Dr. Sandeep Negi (co-PI).

The Effect of Anti-oxidative Coatings on Microelectrode Performance

The major goal of this project is to determine the effects of anti-oxidative coatings on the foreign-body response to established microelectrode platforms implanted cortex and to compare the neural recording properties of coated and uncoated microelectrode arrays. This NIH funded effort R01 NS110823 is a collaborative multi-PI project between Case Western Reserve University Professor Jeffrey Capadona and  UT-Dallas Professor Joseph Pancrazio (co-PI).

3′ End Regulation in Nociceptive Plasticity

Post-transcriptional gene control has emerged as a dominant theme in pain induced plasticity. We focus on Poly(A) binding proteins (PABPs), a conserved family of 3’ end associated factors that regulate translation initiation and play prominent roles in development and memory. This NIH funded effort R01 NS100788 is led by Professor Zachary Campbell (PI) with Professors Theodore Price and Joseph Pancrazio serving as co-investigators.

hIPSC-based DRG Tissue Mimics on Multi-well Microelectrode Arrays as a Tissue Chip Model of Acute and Chronic Nociception

The major goals of this project are to (1) develop an innovative 3D model of acute and chronic nociception using hiPSC sensory neurons and satellite glial cell surrogates on multi-well MEAs and (2) demonstrate quantitative efficiency and preclinical efficacy of this microphysiological system by detecting known modulators of sensory neuron excitability in a sensitized model of chronic nociception This NIH funded effort UG3/UH3 TR003149 is led by the University of Massachusetts Lowell Professor Bryan Black Professor with co-investigators at UT Dallas Professors Zachary Campbell, Michael Burton, and Joseph Pancrazio.