Sheel was born and raised in Plano, Texas. She earned her B.S. degree in Chemistry from The University of Texas at Dallas in 2007 where she carried out research in the laboratory of Professor John Sibert. Then Sheel pursued her graduate studies at the University of California, Berkeley under the supervision of Professor Christopher Chang. Her graduate work focused on the synthesis and application of new small molecule fluorescent probes and related analytical imaging technologies to uncover new roles for transition metals in cellular signaling. After completing her Ph.D. in 2013, she joined the laboratory of Professor Frances Arnold at the California Institute of Technology as an NIH Ruth L. Kirschstein NRSA Postdoctoral Fellow. There she employed a multipronged approach, encompassing protein crystallography, enzymology, and directed evolution to understand the structure-function relationship of nitrating cytochrome P450s, resulting in the discovery of new enzymes and natural products. In August 2016, Sheel came back to The University of Texas at Dallas and joined the faculty in the Department of Chemistry and Biochemistry.