Publications

Highlighted Publications

  1. Joshi P.A., Waterhouse P.D., Kasaian K., Fang H., Gulyaeva O., Sul H.S., Boutros P.C., Khokha R. PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland. Nature Communications, 2019. 10(1): 1760.
  2. Joshi P.A., Waterhouse P.D., Kannan N., Narala S.R., Fang H., Di Grappa M.A., Jackson H.W., Penninger J.M., Eaves C., Khokha R. RANK signaling amplifies WNT-responsive mammary progenitors through R-SPONDIN1. Stem cell reports, 2015. 5(1): p. 31–44.
  3. Sigl V.*, Owusu-Boaitey K.*, Joshi P.A., Kavirayani A., Wirnsberger G., Novatchkova M., Kozieradzki I., Schramek D., Edokobi N., Hersl J., Sampson A., Odai-Afotey A., Lazaro C., Gonzalez-Suarez E., Pujana M.A., Cimba F., Heyn H., Vidal E., Cruickshank J., Berman H., Sarao R., Ticevic M., Uribesalgo I., Tortola L., Rao S., Tan Y., Pfeiler G., Lee E.Y., Bago-Horvath Z., Kenner L., Popper H., Singer C., Khokha R., Jones L.P., Penninger J.M. RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Research, 2016. (26(7): p. 761-74.*contributed equally
  4. Joshi, P.A., Goodwin P.J., Khokha, R. Progesterone Exposure and Breast Cancer Risk. Understanding the Biological Roots. JAMA Oncol., 2015. doi:10.1001/jamaoncol.2015.0512.
  5. Joshi P.A., Di Grappa M.A., Khokha R. Active allies: hormones, stem cells and the niche in adult mammopoiesis. (Feature review) Trends Endocrinol Metab, 2012. 23(6): p. 299-309.
  6. Joshi P.A., Jackson H.W., Beristain A.G., Di Grappa M.A., Mote P., Clarke C., Stingl J., Waterhouse P.D., Khokha R. Progesterone induces adult mammary stem cell expansion. Nature, 2010. 465 (7299): p. 803-7.
  7. Joshi P.A., Chang H., Hamel P.A. Loss of Alx4, a stromally-restricted homeodomain protein, impairs mammary epithelial morphogenesis. Dev Biol, 2006. 297 (1): p. 284-94.

Other Publications

  1. Shiah Y., Tharmapalan S., Casey A.E., Joshi P.A., McKee T.D., Jackson, H.W., Beristain A.G., Chan-Seng-Yue M. A., Bader G.D., Lydon, J.P., Waterhouse, P.D., Boutros P.C., Khokha R. A progesterone-CXCR4 axis controls mammary progenitor cell fate in the adult gland. Stem Cell Reports, 2015. 4: p. 313-322.
  2. Joshi P.A., Goodwin P.J., Khokha, R. Progesterone and synthetic progestin controversies-Reply. JAMA Oncol., 2015. 1(7): p. 987-988. doi:10.1001/jamaoncol.2015.2294
  3. Beristain A.G., Molyneux S.D., Joshi P.A., Pomroy N.C., Di Grappa M.A., Chang M.C., Kirschner L.S., Privé G.G., Pujana. M.A., Khokha R. PKA signaling drives mammary tumorigenesis through Src. Oncogene, 2015. 34: p. 1160–1173.
  4. Alexander, C.M., Joshi P.A., Khokha R. Fully interlocking: A story of teamwork among breast epithelial cells. Dev cell, 2014. 28(2): p. 114-115.
  5. Gorrini C., Baniasadi P.S.,Harris I.S., Silvester J., Inoue S., Snow B., Joshi P.A., Wakeham A., Molyneux S.D., Martin B., Bouwman P., Cescon D.W., Elia A.J., Winterton-Perks Z., Cruickshank J., Brenner D., Tseng A., Musgrave M., Berman H.K., Khokha R., Jonkers J., Mak T.W., Gauthier M.L. BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J exp Med, 2013. 210(8): p. 1529-44.
  6. Lee H.J., Gallego-Ortega D., Ledger A., Schramek, D., Joshi P., Szwarc M.M., Cho C., Lydon J.P., Khokha R., Penninger J.M., Ormandy C.J. Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development, 2013. 140 (7): p. 1397-401.
  7. Joshi P.A., Khokha R. The mammary stem cell conundrum: is it unipotent or multipotent? (viewpoint) Breast Cancer Res, 2012. 14 (2): p. 305-7.
  8. Schramek D., Leibbrandt A., Sigl V., Kenner L., Pospisilik J.A., Lee H.J., Hanada R., Joshi P.A., Aliprantis A., Glimcher L., Pasparakis M., Khokha R., Ormandy C., Widschwendter M., Schett G., Penninger J.M. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature, 2010. 468 (7320): p. 98-102.