Welcome to the De Nisco Lab website. Current research focuses on recurrent urinary tract infection (RUTI) as part of an ongoing clinical collaboration with the Department of Urology at UT Southwestern Medical Center. Our research combines access to clinical samples with techniques from fields of molecular microbiology, cell biology and immunology to discover how both microbe and host contribute to this disease that affects millions of women. Examples of available research projects include:

  1. characterizing the host inflammatory response during RUTI and elucidating its role in recurrence
  2. deciphering the virulence mechanisms of clinically-relevant RUTI pathogens
  3. understanding the impact of the urinary microbiome on UTI recurrence through metagenomics.