Exposomics: the comprehensive, high-resolution analysis of all environmental and lifestyle exposures across the lifespan and frames its methods and insights within the Off Center for Emergence Studies (OC4ES) agenda. After defining the exposome’s external (chemical, physical, social) and internal (biochemical, microbiome, epigenetic) dimensions, we review cutting-edge tools, wearable sensors, high-resolution mass spectrometry, geospatial mapping, and machine-learning integration that enable systematic tracing of exposure–response patterns. We then draw parallels between exposomics’ probe–sense–respond workflows and OC4ES’s transdisciplinary practices, highlighting opportunities to smash academic silos through joint mapping of exposures and departmental networks.
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Lead Author: Roger F Malina, Fred the Heretic and Aperio