Obaid Lab Publications from UT Dallas
PD-L1 Immune Checkpoint Targeted Photoactivable Liposomes (iTPALs) Prime the Stroma of Pancreatic Tumors and Promote Self-Delivery.C. Bhandari, A. Moffat, N. Shah, A. Khan, M. Quaye, J. Fakhry, S. Soma, A. Nguyen, M. Eroy, A. Malkoochi, R. Brekken, T. Hasan, J. Ferruzzi, G. Obaid, Adv. Healthcare Mater. 2024, 2304340. https://doi.org/10.1002/adhm.202304340
Immunofluorescence Profiling of Collagen Subtypes is a Predictor of Treatment Outcomes in Pancreatic Cancer. Girgis Obaid,† Menitte Eroy,† Jie Zhao,† Shazia Bano, Mari Mino-Kenudson, and Tayyaba Hasan. Journal of Photochemistry & Photobiology, B: Biology (2023). In press
A single photodynamic priming protocol augments delivery of ⍺‐PD‐L 1 m A bs and induces immunogenic cell death in head and neck tumors. Chanda Bhandari, Azophi Moffat, John Fakhry, Ashritha Malkoochi, Austin Nguyen, Brian Trinh, Kenneth Hoyt, Michael D. Story, Tayyaba Hasan, and Girgis Obaid. Photochemistry and Photobiology (2023). https://doi.org/10.1111/php.13865
Image-guided focused ultrasound-mediated molecular delivery to breast cancer in an animal model. Ryan Margolis, Lokesh Basavarajappa, Junjie Li, Girgis Obaid, and Kenneth Hoyt. . Physics in Medicine & Biology 68, no. 15 (2023): 155012. https://doi.org/10.1088/1361-6560/ace23d
Automated polarized hyperspectral imaging (PHSI) for ex-vivo and in-vivo tissue assessment. Ma, Ling, Akhila Srinivas, Abirami Krishnamurthy, Ximing Zhou, Nimit Subhashbhai Shah, Girgis Obaid, and Baowei Fei. In Label-free Biomedical Imaging and Sensing (LBIS) 2023, vol. 12391, pp. 88-98. SPIE, 2023.
Nanoliposomes for Photodynamic Drug Delivery: A Multifaceted Approach to Overcome Chemoresistance in Pancreatic Cancer. Mans Broekgaarden, Tristan Le Clainche, Nazareth Carigga Gutierrez, Núria Pujol-Sole, Malika Kadri, Chanda Bhandari, Girgis Obaid, and C. O. L. L. Jean-Luc. Photodiagnosis and Photodynamic Therapy 41 (2023): 103379. https://doi.org/10.1016/j.pdpdt.2023.103379
Photodynamic approaches to alleviate desmoplasia: improving surgical and survival outcomes Girgis Obaid, Chanda Bhandari, Shazia Bano, Kimberley Samkoe, Kenneth Hoyt, Tayyaba Hasan Proceedings Volume PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI; PC1235901 (2023) https://doi.org/10.1117/12.2644727 Event: SPIE BiOS, 2023, San Francisco, California, United States
Automated polarized hyperspectral imaging (PHSI) for ex-vivo and in-vivo tissue assessment. Ling Ma, Akhila Srinivas, Abirami Krishnamurthy, Ximing Zhou, Nimit Subhashbhai Shah, Girgis Obaid, Baowei Fei Proceedings Volume 12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; 123910F (2023) https://doi.org/10.1117/12.2651011
Event: SPIE BiOS, 2023, San Francisco, California, United States
Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer Rickard, B.P., Overchuk, M., Obaid, G., Ruhi, M.K., Demirci, U., Fenton, S.E., Santos, J.H., Kessel, D. and Rizvi, I. (2023) Photochem Photobiol. https://doi.org/10.1111/php.13723
Establishing a Robust and Reliable Response from a Potent Osmium-Based Photosensitizer ViaLipid Nanoformulation Cole, H.D., Eroy, M., Roque, J.A., III, Shi, G., Guirguis, M., Fakhry, J., Cameron, C.G., Obaid, G*. and McFarland, S.A.* (2023), . Photochem Photobiol. https://doi.org/10.1111/php.13756
Remediating Desmoplasia with EGFR-Targeted Photoactivable Multi-Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer. Obaid, G., Bano, S., Thomsen, H., Callaghan, S., Shah, N., Swain, J. W. R., Jin, W., Ding, X., Cameron, C. G., McFarland, S. A., Wu, J., Vangel, M., Stoilova-McPhie, S., Zhao, J., Mino-Kenudson, M., Lin, C., Hasan, T. . Adv. Sci. 2022, 2104594. https://doi.org/10.1002/advs.202104594
Orthotopic Models of Pancreatic Cancer to Study PDT G Obaid, Z Mai, T Hasan – Photodynamic Therapy: Methods and Protocols, 2022
Subcutaneous Xenograft Models for Studying PDT In Vivo G Obaid, T Hasan – Photodynamic Therapy: Methods and Protocols, 2022
Enabling In Vivo Optical Imaging of an Osmium Photosensitizer by Micellar Formulation. Pharmaceutics. Shah D, Eroy M, Fakhry J, Moffat A, Fritz K, Cole HD, Cameron CG, McFarland SA, Obaid G. MDPI Pharmaceutics 2022 Nov https://pubmed.ncbi.nlm.nih.gov/36365244/
Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW Bhandari C, Fakhry J, Eroy M, Song JJ, Samkoe K, Hasan T, Hoyt K, Obaid G. . Front Oncol. 2022 Jun 28;12:853660. 10.3389/fonc.2022.853660
Improved treatment of head and neck cancer using 3-D focused ultrasound-mediated cetuximab drug delivery R Margolis, J Li, M Eroy, D Chanthavisay, G Obaid… – 2022 IEEE International Ultrasonics Symposium (IUS), 2022
Targeting photonanomedicines in cancer therapy: stromal, cellular and subcellular photomodulation Girgis Obaid, Shazia Bano, Kimberley S. Samkoe, Imran Rizvi, Brian W. Pogue, David H. Kessel, andTayyaba Hasan , Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2624625
Deep-Tissue Activation of Photonanomedicines: An Update and Clinical Perspectives. Shah, Nimit, John Squire, Mina Guirguis, Debabrata Saha, Kenneth Hoyt, Ken Kang-Hsin Wang, Vijay Agarwal, and Girgis Obaid. Cancers 14, no. 8 (2022): 2004. https://doi.org/10.3390/pharmaceutics13060786
Biomimetic Nanotechnology: A Natural Path Forward for Tumor-Selective and Tumor-Specific NIR Activable Photonanomedicines. Prajapati, S., Hinchliffe, T., Roy, V., Shah, N., Jones, C.N. and Obaid, G., 2021. Pharmaceutics, 13(6), p.786. https://www.mdpi.com/1999-4923/13/6/786
Membrane composition is a functional determinant of NIR-activable liposomes in orthotopic head and neck cancer. Guirguis, M., Bhandari, C., Li, J., Eroy, M., Prajapati, S., Margolis, R., Shrivastava, N., Hoyt, K., Hasan, T. and Obaid, G., 2021. Nanophotonics. https://www.degruyter.com/document/doi/10.1515/nanoph-2021-0191/html
What NIR photodynamic activation offers molecular targeted nanomedicines: Perspectives into the conundrum of tumor specificity and selectivity. Bhandari, C., Guirguis, M., Savan, N.A., Shrivastava, N., Oliveira, S., Hasan, T. and Obaid, G., 2021. Nano Today, 36, p.101052. https://www.sciencedirect.com/science/article/pii/S174801322030222X
Photoimmunotherapy Retains Its Anti-Tumor Efficacy with Increasing Stromal Content in Heterotypic Pancreatic Cancer Spheroids Mohammad A. Saad, Wonho Zhung, Margaret Elizabeth Stanley, Sydney Formica, Stacey Grimaldo-Garcia, Girgis Obaid, and Tayyaba HasanMolecular Pharmaceutics 2022 19 (7), 2549-2563DOI: 10.1021/acs.molpharmaceut.2c00260
Critical PDT theory II: Current concepts and indications. David Kessel, Girgis Obaid, Imran Rizvi, Photodiagnosis and Photodynamic Therapy, Volume 39, 2022, 102923, ISSN 1572-1000, https://doi.org/10.1016/j.pdpdt.2022.102923
Is tumor cell specificity distinct from tumor selectivity in vivo? A quantitative NIR molecular imaging analysis of nanoliposome targeting. Obaid, G., Samkoe, K., Tichauer, K. et al. Nano Res. 14, 1344–1354 (2021). https://doi.org/10.1007/s12274-020-3178-x
NIR Photodynamic Destruction of PDAC and HNSCC Nodules Using Triple-Receptor-Targeted Photoimmuno-Nanoconjugates: Targeting Heterogeneity in Cancer. Bano, S.; Obaid, G.; Swain, J.W.R.; Yamada, M.; Pogue, B.W.; Wang, K.; Hasan, T. J. Clin. Med.2020, 9, 2390. https://doi.org/10.3390/jcm908239
Previous Publications
Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors. Broekgaarden, M.; Alkhateeb, A.; Bano, S.; Bulin, A.-L.; Obaid, G.; Rizvi, I.; Hasan, T. Cancers 2020, 12, 1401. https://doi.org/10.3390/cancers12061401
Abstract A17: Enhanced immune infiltration and antitumor immune reactivity in response to optical priming in pancreatic cancer. Cancer Immunol Res 1 March 2020; 8 (3_Supplement): A17.Pushpamali De Silva, Mohammad Ahsan Saad, Assiris P. Camargo, Joseph Swain, Akilan Palanasami, Girgis Obaid, Shalin Shetty, Tayyaba Hasan; https://doi.org/10.1158/2326-6074.TUMIMM19-A17
The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T-Cell Repertoire. Nath S, Obaid G, Hasan T. Photochem Photobiol. 2019 Nov;95(6):1288-1305. https://doi.org/10.1111/php.13173
Targeted PDT-based combinations for cancer: sub-cellular sites and cytotoxic mechanisms (Conference Presentation) Imran Rizvi, Girgis Obaid, Shubhankar Nath, Mustafa K. Ruhi, Kaitlin Moore, Shazia Bano, David Kessel,and Tayyaba Hasan , Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110702D (14 August 2019); https://doi.org/10.1117/12.2525889
Nanolipid Formulations of Benzoporphyrin Derivative: Exploring the Dependence of Nanoconstruct Photophysics and Photochemistry on Their Therapeutic Index in Ovarian Cancer Cells. Obaid G, Jin W, Bano S, Kessel D, Hasan T. Photochem Photobiol. 2019 Jan;95(1):364-377. https://doi.org/10.1111/php.13002
Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates: Towards Conquering Desmoplasia? Obaid G, Bano S, Mallidi S, Broekgaarden M, Kuriakose J, Silber Z, Bulin AL, Wang Y, Mai Z, Jin W, Simeone D, Hasan T. Nano Lett. 2019 Nov 13;19(11):7573-7587. https://doi.org/10.1021/acs.nanolett.9b00859
A Combination of Visudyne and a Lipid-anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer. Rizvi, I., Nath, S., Obaid, G., Ruhi, M.K., Moore, K., Bano, S., Kessel, D. and Hasan, T. (2019), Photochem Photobiol, 95: 419-429. https://doi.org/10.1111/php.13066
Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer. Mans Broekgaarden, Sriram Anbil, Anne-Laure Bulin, Girgis Obaid, Zhiming Mai, Yan Baglo, Imran Rizvi, Tayyaba Hasan,Biomaterials Volume 222, 2019, 119421, ISSN 0142-9612, https://doi.org/10.1016/j.biomaterials.2019.119421.
Liposomal Lapatinib in Combination with Low-Dose Photodynamic Therapy for the Treatment of Glioma. Fisher, C.; Obaid, G.; Niu, C.; Foltz, W.; Goldstein, A.; Hasan, T.; Lilge, L. J. Clin. Med. 2019, 8, 2214. https://doi.org/10.3390/jcm8122214
Photodynamic therapy-based combinations to overcome molecular, cellular and stromal resistance mechanisms in ovarian and pancreatic cancer Proceedings Volume 10476, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII; 1047604 (2018) https://doi.org/10.1117/12.2290472
Event: SPIE BiOS, 2018, San Francisco, California, United States
Chemically Tuned NIR Light-Activated Bionanoconjugates for the Selective Destruction of Tumor Cells in Heterocellular 3D Models and for Quantitative In Vivo tumor Imaging G Obaid, S Bano, K Samkoe, S Mallidi, J Kuriakose… – 2018 AIChE Annual Meeting, 2018
Strategic Advancement of Targeted Nanomedicines: Intelligent Bio-Nanoengineering Using Molecular Imaging in 3D and In Vivo tumor Models G Obaid – 2018 AIChE Annual Meeting, 2018
Heterocellular 3D platforms and in vivo dual-nanotracer molecular imaging provide clinically-relevant insights to facilitate the development of antibody-targeted, NIR-active nanotherapeutics G Obaid, S Bano, K Samkoe, S Mallidi, J Kuriakose… – ABSTRACTS OF PAPERS OF THE AMERICAN …, 2018
Photodynamic therapy: Promoting in vitro efficacy of photodynamic therapy by liposomal formulations of a photosensitizing agent. Rizvi I, Obaid G, Bano S, Hasan T, Kessel D. Lasers Surg Med. 2018 Jul;50(5):499-505. https://doi.org/10.1002/lsm.22813.
CANCER THERAPEUTICS WITH LIGHT: ROLE OF NANOSCALE AND TISSUE ENGINEERING IN PHOTODYNAMIC THERAPY Joyce Liu (), Huang-Chiao Huang (), Emma Briars (), Girgis Obaid (), Imran Rizvi (), and Tayyaba Hasan ()Cancer Therapeutics and Imaging. January 2018, 219-260
Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery. Obaid G, Spring BQ, Bano S, Hasan T. J Biomed Opt. 2017 Aug;22(12):1-6. https://doi.org/10.1117/1.JBO.22.12.121607
Targeted Photodynamic Therapy—An Assimilation of Successes, Challenges and Future Directions. Girgis Obaid, Huang-Chiao Huang, Tayyaba Hasan, 2016. Photodynamic Medicine: From Bench to Clinic, Herwig Kostron, Tayyaba Hasan https://doi.org/10.1039/9781782626824-00137
Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy. Mallidi S, Anbil S, Bulin AL, Obaid G, Ichikawa M, Hasan T. Theranostics. 2016 Oct 23;6(13):2458-2487. https://doi.org/10.7150/thno.16183.
Photonanomedicine: a convergence of photodynamic therapy and nanotechnology. Obaid G, Broekgaarden M, Bulin AL, et al. Nanoscale. 2016;8(25):12471-12503. https://doi.org/10.1039/c5nr08691d
Site-specific antibody-liposome conjugation through copper-free click chemistry: a molecular biology approach for targeted photodynamic therapy (Conference Presentation) Girgis Obaid, Yucheng Wang, Jerrin Kuriakose, Mans Broekgaarden, Ahmed Alkhateeb, Anne-Laure Bulin, James Hui, Andrew Tsourkas, and Tayyaba Hasan “, Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940U (26 April 2016); https://doi.org/10.1117/12.2214253
Advancing photodynamic therapy with biochemically tuned liposomal nanotechnologies. H-C. Huang, S. Mallidi, G. Obaid, B. Sears, S. Tangutoori, T. Hasan, Applications of Nanoscience in Photomedicine, Chandos Publishing, 2015, Pages 487-510, ISBN 9781907568671, https://doi.org/10.1533/9781908818782.487.
Examining the effect of liposomal lapatinib in combination with PDT for the treatment of malignant gliomas C Fisher, C Niu, W Foltz, G Obaid, T Hasan, L Lilge – Photodiagnosis and Photodynamic Therapy, 2015. 10.1016/j.pdpdt.2015.07.074
Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles. Obaid, G., Chambrier, I., Cook, M.J. et al. Photochem Photobiol Sci 14, 737–747 (2015). https://doi.org/10.1039/c4pp00312h
Targeted nanoparticle platforms for selective photodynamic therapy of cancer G Obaid – 2013
Nanoparticles for photodynamic cancer therapy G Obaid, DA Russell – Handbook of photomedicine, 2013
Targeting the oncofetal Thomsen-Friedenreich disaccharide using jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy. Obaid G, Chambrier I, Cook MJ, Russell DA. . Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6158-62. https://doi.org/10.1002/anie.201201468