2024:
Nguyen LH, Xu Y, Nair M, Bordey A. The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. Elife.2024 Feb 27;12. doi: 10.7554/eLife.91010. PMID: 38411613; PMCID: PMC10942629.
2023:
Nguyen LH, Sharma M, Bordey A. 4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice. Front Neurosci. 2023;17:1257056. doi: 10.3389/fnins.2023.1257056. eCollection 2023. PMID: 37680968; PMCID: PMC10480503.
2022 and Before:
Nguyen LH, Bordey A. Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy. Epilepsy Curr. 2022 Jul-Aug;22(4):234-240. doi: 10.1177/15357597221098230. eCollection 2022 Jul-Aug. Review. PMID: 36187145; PMCID: PMC9483763.
Nguyen LH, Xu Y, Mahadeo T, Zhang L, Lin TV, Born HA, Anderson AE, Bordey A. Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy. Brain. 2022 May 24;145(4):1310-1325. doi: 10.1093/brain/awab390. PMID: 34849602; PMCID: PMC9128821.
Nguyen LH, Leiser SC, Song D, Brunner D, Roberds SL, Wong M, Bordey A. Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex. Epilepsy Res. 2022 Mar;181:106890. doi: 10.1016/j.eplepsyres.2022.106890. Epub 2022 Feb 18. PMID: 35219048; PMCID: PMC8930622.
Nguyen LH, Bordey A. Corrigendum: Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies. Front Neuroanat. 2021;15:715363. doi: 10.3389/fnana.2021.715363. eCollection 2021. PMID: 34295225; PMCID: PMC8290855.
Nguyen LH, Bordey A. Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies. Front Neuroanat. 2021;15:664695. doi: 10.3389/fnana.2021.664695. eCollection 2021. Review. PMID: 33897381; PMCID: PMC8064518.
Hsieh LS, Wen JH, Nguyen LH, Zhang L, Getz SA, Torres-Reveron J, Wang Y, Spencer DD, Bordey A. Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice. Sci Transl Med.2020 Nov 18;12(570). doi: 10.1126/scitranslmed.abc1492. PMID: 33208499; PMCID: PMC9888000.
Zhang L, Huang T, Teaw S, Nguyen LH, Hsieh LS, Gong X, Burns LH, Bordey A. Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations. Sci Transl Med.2020 Feb 19;12(531). doi: 10.1126/scitranslmed.aay0289. PMID: 32075941.
Huang T, Nguyen LH, Lin TV, Gong X, Zhang L, Kim GB, Sarkisian MR, Breunig JJ, Bordey A. In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neurosci Res. 2019 Jun;143:44-52. doi: 10.1016/j.neures.2018.05.006. Epub 2018 May 29. PMID: 29857015; PMCID: PMC6265126.
Nguyen LH, Mahadeo T, Bordey A. mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia. J Neurosci. 2019 Apr 3;39(14):2762-2773. doi: 10.1523/JNEUROSCI.2260-18.2019. Epub 2019 Jan 30. PMID: 30700531; PMCID: PMC6445990.
Nguyen LH, Anderson AE. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Sci Rep.2018 Feb 23;8(1):3568. doi: 10.1038/s41598-018-21656-8. PMID: 29476105; PMCID: PMC5824782.
Nguyen LH, Brewster AL, Clark ME, Regnier-Golanov A, Sunnen CN, Patil VV, D’Arcangelo G, Anderson AE. mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia. Epilepsia. 2015 Apr;56(4):636-46. doi: 10.1111/epi.12946. Epub 2015 Mar 6. PMID: 25752454; PMCID: PMC4459784.