Publications

Adam Shebindu, Durga Kaveti, Linda Umutoni, Gia Kirk, Michael D Burton, Caroline N Jones

A programmable microfluidic platform to monitor calcium dynamics in microglia during inflammation

Microsystems & Nanoengineering
https://www.nature.com/articles/s41378-024-00733-1

Shuai Shao, Nikki A Delk, Caroline N Jones

A microphysiological system reveals neutrophil contact-dependent attenuation of pancreatic tumor progression by CXCR2 inhibition-based immunotherapy

Scientific Reports
https://www.nature.com/articles/s41598-024-64780-4

Pegah Haghighi, Mandee K Schaub, Adam H Shebindu, Gayathri Vijayakumar, Armaan Sood, Rafael Granja-Vazquez, Sourav S Patnaik, Caroline N Jones, Gregory O Dussor, Joseph J Pancrazio

In Vitro Pharmacological Modulation of PIEZO1 Channels in Frontal Cortex Neuronal Networks

Brain Sciences
https://www.mdpi.com/2076-3425/14/3/223

Udaya Sree Datla, Bhaskar Vundurthy, Jessica S Hook, Nidhi Menon, Hossein Razmi Bagtash, Tarik Shihabeddin, David W Schmidtke, Jessica G Moreland, Marko Z Radic, Caroline N Jones

Quantifying neutrophil extracellular trap release in a combined infection–inflammation NET-array device

Royal Society of Chemistry
https://pubs.rsc.org/en/content/articlehtml/2024/lc/d3lc00648d

Udaya Sree Datla, Bhaskar Vundurthy, Jessica S Hook, Nidhi Menon, Hossein Razmi Bagtash, Tarik Shihabeddin, David W Schmidtke, Jessica G Moreland, Marko Z Radic, Caroline N Jones

Quantifying neutrophil extracellular trap release in a combined infection–inflammation NET-array device

The Royal Society Publishing
https://pubs.rsc.org/en/content/articlehtml/2024/lc/d3lc00648d

Indira Neeli , Maryam Moarefian , Jayalakshmi Kuseladass , Nishant Dwivedi , Caroline Jones  and Marko Radic

Neutrophil attachment via Mac-1 (αMβ2; CD11b/CD18; CR3) integrins induces PAD4 deimination of profilin and histone H3

The Royal Society Publishing
https://royalsocietypublishing.org/doi/abs/10.1098/rstb.2022.0247

Caroline N. Jones;  Udaya Sree Datla

Combined Infection-Inflammation Microsystem to Quantify NETosis

The Journal of Immunology
https://journals.aai.org/jimmunol/article/210/1_Supplement/251.22/263932

Maryam Moarefian, Rafael V. Davalos, Michael D. Burton, Caroline N. Jones

Electrotaxis-on-Chip to Quantify Neutrophil Migration Towards Electrochemical Gradients

Frontiers in Immunology
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.674727/full

Xin He, Brad A. Howard, Yang Liu, Aaron K. Neumann, Liwu Li, Nidhi Menon, Tiffany Roach,  Shiv D. Kale, David C. Samuels,  Hongyan Li, Trenton Kite,  Hirohito Kita, Tony Y. Hu,  Mengyao Luo,  Caroline N. Jones, Uju Joy Okaa, Diane L. Squillace,  Bruce S. Klein, Christopher B. Lawrence

LYSMD3: A mammalian pattern recognition receptor for chitin

Cell Reports
https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00790-7

Sushant Prajapati, Taylor Hinchliffe, Vinay Roy, Nimit Shah, Caroline N. Jones, and Girgis Obaid

Biomimetic Nanotechnology: A Natural Path Forward for Tumor-Selective and Tumor-Specific NIR Activable Photonanomedicines

Pharmaceutics
https://www.mdpi.com/1999-4923/13/6/786

Marisela M. Davis, Aaron M. Brock, Tanner G. DeHart, Brittany P. Boribong, Katherine Lee, Mecaila E. McClune, Yunjie Chang, Nicholas Cramer, Jun Liu, Caroline N. Jones, Brandon L. Jutras

The peptidoglycan-associated protein NapA plays an important role in the envelope integrity and in the pathogenesis of the lyme disease spirochete

TPLOS Pathogens
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009546

Leila Abdelhamid;  Xavier Cabana-Puig;  Qinghui Mu;  Maryam Moarefian;  Brianna Swartwout;  Kristin Eden;  Prerna Das;  Ryan P. Seguin; Libin Xu;  Sarah Lowen;  Mital Lavani;  Terry C. Hrubec;  Caroline N Jones;  Xin M. Luo

Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate

The Journal of Immunology
https://journals.aai.org/jimmunol/article/206/1_Supplement/60.02/238273

Stanca M. Ciupe, Brittany P. Boribong, Sarah Kadelka, Caroline N. Jones

Bistable Mathematical Model of Neutrophil Migratory Patterns After LPS-Induced Epigenetic Reprogramming

Frontiers
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.674727/full

Leila Abdelhamid,  Xavier Cabana-Puig, Qinghui Mu, Maryam Moarefian, Brianna Swartwout, Kristin Eden, Prerna Das, Ryan P. Seguin, Libin Xu, Sarah Lowen, Mital Lavani, Terry C. Hrubec, Caroline N. Jones,  Xin M. Luo

Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate

Frontiers
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.575179/full

Sushant Prajapati, Taylor Hinchliffe, Vinay Roy, Nimit Shah, Caroline N. Jones, and Girgis Obaid

Biomimetic Nanotechnology: A Natural Path Forward for Tumor-Selective and Tumor-Specific NIR Activable Photonanomedicines

Pharmaceutics
https://www.mdpi.com/1999-4923/13/6/786

Maryam Moarefian a, Rafael V. Davalos  ORCID logob, Danesh K. Tafti a, Luke E. Achenie c and Caroline N. Jones

Modeling iontophoretic drug delivery in a microfluidic device

Royal Society of Chemistry
https://pubs.rsc.org/en/content/articlehtml/2020/lc/d0lc00602e

Jones CN, Ellett F, Robertson AL, Forrest KM, Judice K, Balkovec JM, Springer M, Markmann JF, Vyas JM, Warren HS, Irimia D.

Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro.

Front Immunol. 2019 Apr 9;10:644. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465576/

Boribong BP, Lenzi MJ, Li L, Jones CN.

Super-Low Dose Lipopolysaccharide Dysregulates Neutrophil Migratory Decision-Making.

Front Immunol. 2019 Mar 12;10:359. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422936/

Boribong BP, Rahimi A, Jones CN.

Microfluidic Platform to Quantify Neutrophil Migratory Decision-Making.

Methods Mol Biol. 2019;1960:113-122. https://www.ncbi.nlm.nih.gov/pubmed/30798526

Datla US, Mather WH, Chen S, Shoultz IW, Täuber UC, Jones CN, Butzin NC.

The spatiotemporal system dynamics of acquired resistance in an engineered microecology.

Sci Rep. 2017 Nov 22;7(1):16071. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700104/

Ellett F, Jorgensen J, Frydman GH, Jones CN, Irimia D.

Neutrophil Interactions Stimulate Evasive Hyphal Branching by Aspergillus fumigatus.

PLoS Pathog. 2017 Jan 11;13(1):e1006154. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261818/

Jones CN, Hoang AN, Martel JM, Dimisko L, Mikkola A, Inoue Y, Kuriyama N, Yamada M, Hamza B, Kaneki  M, Warren HS, Brown DE, Irimia D.

Microfluidic assay for precise measurements of mouse, rat, and human neutrophil chemotaxis in whole-blood droplets.

J Leukoc Biol. 2016 Jul;100(1):241-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608085/

Jones CN, Dimisko L, Forrest K, Judice K, Poznansky MC, Markmann JF, Vyas JM, Irimia D.

Human Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of Aspergillus fumigatus.

J Infect Dis. 2016 Feb 1;213(3):465-75.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704668

Jones CN*, Hoang AN*, Dimisko L, Hamza B, Martel J, Irimia D.

Microfluidic platform for measuring neutrophil chemotaxis from unprocessed whole blood.

J Vis Exp. 2014 Jun 3;(88). *Equal contribution. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186496/

Jones CN, Moore M, Dimisko L, Alexander A, Ibrahim A, Hassell BA, Warren HS, Tompkins RG, Fagan SP, Irimia D.

Spontaneous neutrophil migration as a clinical biomarker for sepsis in human burn patients.

PLoS One. 2014 Dec 9;9(12):e114509. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260850/

Hoang A*, Jones CN*, Dimisko L, Hamza B, Martel J, Irimia D.

Measuring neutrophil speed and directionality during chemotaxis, directly from a droplet of whole blood.

Technology (Singap World Sci). 2013 Oct 2;1(1):49. *Equal contribution. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010229/

Kurihara T, Jones CN, Yu YM, Fischman AJ, Watada S, Tompkins RG, Fagan SP, Irimia D.

Resolvin D2 restores neutrophil directionality and improves survival after burns.

FASEB J. 2013 Jun;27(6):2270-81. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659356/

Patel D, Haque A, Jones CN, Tuleouva N, Foster E, Vu T, Reddi AH, Revzin A.

Local control of hepatic phenotype with growth factor-encoded surfaces.

Integrative Biology. 2013 Dec;6(1):44-52. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331075/

Jones CN, Dalli J, Dimisko L, Wong E, Serhan CN, Irimia D.

Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions.

Proc. Natl. Acad. Sci. U.S.A. 2012;109(50):20560-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528552/

Hoerning A, Koss K, Datta D, Boneschansker L, Jones CN, Wong IY, Irimia D, Calzadilla K, Benitez F, Hoyer PF, Harmon WE, Briscoe DM.

Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3.

Eur J Immunol. 2011;41(8):2291-302. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383044/

Kim M, Lee JY, Jones CN, Revzin A, Tae G.

Heparin-Based Hydrogel as a Matrix for Encapsulation and Cultivation of Primary Hepatocytes.

Biomaterials. 2010; 31(13):3596-603. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837121/

Tuleuova N, Jones CN, Yan J, Ramanculov E, Yokobayashi Y, Revzin A.

Development of an aptamer beacon for detection of interferon-gamma.

Anal Chem. 2010 Mar 1;82(5):1851-7. https://www.ncbi.nlm.nih.gov/pubmed/20121141

Jones CN, Tuleuova N, Lee JY, Ramanculov E, Reddi AH, Zern MA, Revzin A.

Cultivating hepatocytes on printed arrays of HGF and BMP7 to characterize protective effects of these growth factors during in vitro alcohol injury.

Biomaterials. 2010;31(23):5936-44. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893270/

Lee JY, Tuleuova N, Jones CN, Ramanculov E, Zern MA, Revzin A.

Directing hepatic differentiation of embryonic stem cells with protein microarray-based co-cultures.

Integr Biol (Camb). 2009 Jul;1(7):460-8. https://www.ncbi.nlm.nih.gov/pubmed/20023756

Jones CN, Tuleuova N, Lee JY, Ramanculov E, Reddi AH, Zern MA, Revzin A.

Cultivating liver cells on printed arrays of hepatocyte growth factor.

Biomaterials. 2009 Aug;30(22):3733-41. https://www.ncbi.nlm.nih.gov/pubmed/19375794

Jones CN, Lee JY, Zhu J, Stybayeva G, Ramanculov E, Zern MA, Revzin A.

Multifunctional protein microarrays for cultivation of cells and immunodetection of secreted cellular products.

Anal Chem. 2008 Aug 15;80(16):6351-7. https://www.ncbi.nlm.nih.gov/pubmed/18642875

Zhu H, Macal M, Jones CN, George MD, Dandekar S, Revzin A.

A miniature cytometry platform for capture and characterization of T-lymphocytes from human blood.

Anal Chim Acta. 2008 Feb 11;608(2):186-96. https://www.ncbi.nlm.nih.gov/pubmed/18215650