Publications

94. Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library

Iannuzzelli JA, Bonn RMS, Hong A, Saseendran Anitha A, Wedekind* JE, Fasan* R

Preprint: Chem. Rxiv. 2024.

93. Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles

Roy S, Wang Y, Zhao X, Chu JM, Zhang* Y and Fasan* R

J. Am. Chem. Soc. 2024, 146, 1973 – 19679 PDF.

92. Chemoenzymatic Skeletal Editing: P450-Controlled Site-Selective Ring Expansion of Natural Product Scaffolds at Aliphatic C—H Sites

Bortz A, Bennett J, and Fasan* R

Preprint: Chem. Rxiv. 2024.

91. A Skeletally Diverse Library of Bioactive Natural Product-Like Compounds Enabled by Late-Stage P450-Catalyzed Oxyfunctionalization

Bortz A, Bennett J, and Fasan* R

Chem. 2024, 10, 1- 15, PDF.

90. Radical-Mediated Regiodivergent C(sp3)–H Functionalization of N-Substituted Indolines via Enzymatic Carbene Transfer

Couture B, Cui R, Chu JM, Zhang Y and Fasan* R

Chem. Rxiv. 2024, accepted PDF.

89. Chemoenzymatic synthesis of optically active α-cyclopropyl-pyruvates and cyclobutenoates via enzyme-catalyzed carbene transfer with diazopyruvate

Dollet R, Villada JD, Poisson T, Fasan* R and Jubault P*

Org. Chem. Front. 2024,11, 2008-2014 PDF.

88. Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes

Villada JD, Majhi J, Lehuédé V, Hendricks ME, Neufeld K, Tona* V, and Fasan* R

Angew. Chem. Int. Ed. 2024, accepted PDF.

87. Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone

Nam D, Bacik JP, Khade RL, Aguilera MC, Wei Y, Villada JD, Neidig* ML, Zhang* Y, Ando* N, and Fasan* R

Nat. Commun. 2023,14, 7985 PDF.

86. Enantioselective single and dual a-C–H bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Ren X, Couture BM, Liu N, Lall MS, Kohrt JT, and Fasan* R

J. Am. Chem. Soc. 2023, 145, 1, 537–550 PDF.

85. Dehaloperoxidase Catalyzed Stereoselective Synthesis of Cyclopropanol Esters

Siriboe MG, Vargas DA, and Fasan* R

J. Org. Chem. 2023, 88, 12, 7630–7640 PDF.

84. Engineered Myoglobin Catalysts for Asymmetric Intermolecular Cyclopropanation Reactions

Siriboe MG, and Fasan* R

Bull. Chem. Soc. Jpn. 2022; 80 4-13 PDF.

→ Award Review Article

83. Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases

Ren X, Chandgude AL, Carminati DM, Shen Z, Khare SD and Fasan* R

Chem. Sci. 2022;13 8550–8556 PDF.

82. Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization

Iannuzzelli JA, Bacik JP, Moore EJ, Shen Z, Irving EM, Vargas DA, Khare* SD, Ando* N, and Fasan* R

Biochemistry 2022; 61, 11, 1041–1054 PDF

81. Enantioselective Synthesis of alpha-Trifluoromethyl Amines via Biocatalytic N–H Bond Insertion with Acceptor-Acceptor Carbene Donors

Nam D, Tinoco A, Shen Z, Adukure RD, Sreenilayam D, Khare* SD, and Fasan* R

J. Am. Chem. Soc. 2022; 144 (6) 2590–2602 PDF