Publications

98. Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library

Iannuzzelli JA, Bonn RMS, Hong A, Saseendran Anitha A, Wedekind* JE, Fasan* R

Chem. Sci. 2024, in press PDF.



→ Highlighted in Chemical & Engineering News


95. Radical-Mediated Regiodivergent C(sp3)–H Functionalization of N-Substituted Indolines via Enzymatic Carbene Transfer

Couture BM, Ru C, Chu J-M, Zhang* Y, Fasan* R

Chem Catalysis 2024, Preprint on ChemRxiv PDF.


94. Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridyltriazoles

Roy S, Wang Y, Zhao X, Dayananda T, Chu J-M, Zhang* Y, Fasan* R

J. Am. Chem. Soc. 2024, 146 (29), 19673-19679 PDF.


93. Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes

Villada Morales J, Majhi J, Lehuédé V, Hendricks ME, Neufeld K, Tona V, Fasan* R

Angew. Chem. Int. Ed. 2024, accepted PDF.

→ Highlighted as “Very Important Paper”



91. Stereoselective Construction of β-, γ-, and δ-Lactam Rings via Enzymatic C–H Amidation

Royǂ S, Vargasǂ DA, Ma P, Sengupta A, Zhu L, Houk* KN, Fasan* R, (ǂ equal contribution)

Nat. Catal. 2024, 7, 65–76 PDF.

→ Highlighted in Chemical & Engineering News

→ Highlighted in Chemistry World

→ Highlighted in Synfacts and selected as “SynFact of the Month”


90. Biocatalytic Strategy for Construction of sp3-Rich Polycyclic Compounds from Directed Evolution and Computational Modeling

Vargasǂ DA, Renǂ X, Senguptaǂ A, Zhu L, Roy S, Garcia-Borràs M, Houk* KN, Fasan* R, (ǂ equal contribution)

Nat. Chem. 2024, 16, 817-826 PDF.


89. Mechanistic Manifold in a Hemoprotein-Catalyzed Cyclopropanation Reaction with Diazoketone

Namǂ D, Bacikǂ JP, Khadeǂ RL, Aguilera MC, Wei Y, Neidig* ML, Zhang* Y, Ando* N, Fasan* R, (ǂ equal contribution)

Nat. Commun. 2023, 14, 7985 PDF.


88. Enantioselective single and dual α-C–H bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Ren X, Couture BM, Liu N, Lall MS, Kohrt JT, Fasan* R

J. Am. Chem. Soc. 2023, 145 (1), 537-550 PDF.

→ Highlighted in Natural Product Reports


87. Dehaloperoxidase Catalyzed Stereoselective Synthesis of Cyclopropanol Esters

Siriboe MG, Vargas DA, Fasan* R

J. Org. Chem. 2023, 88 (12), 7630-7640 PDF.


86. Cellular Validation of Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2

Gan J, de Vries J, Akkermans J, Mohammed Y, Tjokrodirijo R, de Ru A, Kim R, Vargas DA, Pol V, Fasan R, van Veelen P, Neefjes J, Dam H, Ovaa H, Sapmaz A, Geurink P

ACS Chem. Biol. 2023, 18 (9), 2003-2013 PDF.


85. Engineered Myoglobin Catalysts for Asymmetric Intermolecular Cyclopropanation Reactions

Siriboe MG, Fasan* R

Bull. Jpn. Soc. Coord. Chem. 2022, 804-13 PDF.

→ Award Review Article


84. Highly Stereoselective and Enantiodivergent Synthesis of Cyclopropylphosphonates with Engineered Carbene Transferases

Ren X, Chandgude AL, Carminati DM, Fasan* R

Chem. Sci. 2022, 13, 8550-8556 PDF.


83. Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization

Iannuzzelliǂ JA, Bacikǂ JP, Moore EJ, Shen Z, Irving EM, Vargas DA, Khare* SD, Ando* N, Fasan* R (ǂ equal contribution)

Biochem. 2022, 61 (11), 1041-1054 PDF.


82. Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N−H Bond Insertion with Acceptor-Acceptor Carbene Donors

Namǂ D, Tinocoǂ A, Shen Z, Adukure RD, Sreenilayam G, Khare* SD, Fasan* R, (ǂ equal contribution)

J. Am. Chem. Soc. 2022, 144 (6), 2590-2602 PDF.


81. Nanoparticle-Mediated Delivery of Micheliolide Analogs to Eliminate Leukemic Stem Cells in the Bone Marrow

Ackun-Farmmer MA, Alwaseem H, Counts M, Bortz A, Giovani S, Frisch* BJ, Fasan* R, Benoit DSW

Adv. Ther. 2022, 5 (1), 2100100 PDF.


For older publications, please visit our Past Publications page.