Publications

98. Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library

Iannuzzelli JA, Bonn RMS, Hong A, Saseendran Anitha A, Wedekind* JE, Fasan* R

2024, Submitted. Preprint on ChemRxiv PDF.

97. Chemoenzymatic Skeletal Editing: P450-Controlled Site-Selective Ring Expansion of Natural Product Scaffolds at Aliphatic C—H Sites

Bennett JM, Bortz AR, Fasan* R

2024, Submitted. Preprint on ChemRxiv PDF.

96. A Skeletally Diverse Library of Bioactive Natural Product-Like Compounds Enabled by Late-Stage P450-Catalyzed Oxyfunctionalization

Bortz AR, Bennett JM, Fasan* R

Chem 2024, in press PDF.

95. Radical-Mediated Regiodivergent C(sp3)–H Functionalization of N-Substituted Indolines via Enzymatic Carbene Transfer

Couture BM, Ru C, Chu J-M, Zhang* Y, Fasan* R

Chem Catalysis 2024, Preprint on ChemRxiv PDF.

94. Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridyltriazoles

Roy S, Wang Y, Zhao X, Dayananda T, Chu J-M, Zhang* Y, Fasan* R

J. Am. Chem. Soc. 2024, 146 (29), 19673-19679 PDF.

93. Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes

Villada Morales J, Majhi J, Lehuédé V, Hendricks ME, Neufeld K, Tona V, Fasan* R

Angew. Chem. Int. Ed. 2024, accepted PDF.

92. Chemoenzymatic synthesis of optically active α-cyclopropyl-pyruvates and cyclobutenoates via enzyme-catalyzed carbene transfer with diazopyruvate

Villada Morales J, Fasan* R, Jubault* P.

Org. Chem. Front. 2024, 11, 2008-2014 PDF.

91. Stereoselective Construction of β-, γ-, and δ-Lactam Rings via Enzymatic C–H Amidation

Royǂ S, Vargasǂ DA, Ma P, Sengupta A, Zhu L, Houk* KN, Fasan* R, (ǂ equal contribution)

Nat. Catal. 2024, 7, 65–76 PDF.

90. Biocatalytic Strategy for Construction of sp3-Rich Polycyclic Compounds from Directed Evolution and Computational Modeling

Vargasǂ DA, Renǂ X, Senguptaǂ A, Zhu L, Garcia-Borràs M, Houk* KN, Fasan* R, (ǂ equal contribution)

Nat. Chem. 2024, 16, 817-826 PDF.

89. Mechanistic Manifold in a Hemoprotein-Catalyzed Cyclopropanation Reaction with Diazoketone

Namǂ D, Bacikǂ JP, Khadeǂ RL, Aguilera MC, Wei Y, Neidig* ML, Zhang* Y, Ando* N, Fasan* R, (ǂ equal contribution)

Nat. Commun. 2023, 14, 7985 PDF.

88. Enantioselective single and dual α-C–H bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Ren X, Couture BM, Liu N, Lall MS, Kohrt JT, Fasan* R

J. Am. Chem. Soc. 2023, 145 (1), 537-550 PDF.

87. Dehaloperoxidase Catalyzed Stereoselective Synthesis of Cyclopropanol Esters

Siriboe MG, Vargas DA, Fasan* R

J. Org. Chem. 2023, 88 (12), 7630-7640 PDF.

86. Cellular Validation of Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2

Gan J, de Vries J, Akkermans J, Mohammed Y, Tjokrodirijo R, de Ru A, Kim R, Vargas DA, Pol V, Fasan R, van Veelen P, Neefjes J, Dam H, Ovaa H, Sapmaz A, Geurink P

ACS Chem. Biol. 2023, 18 (9), 2003-2013 PDF.

85. Engineered Myoglobin Catalysts for Asymmetric Intermolecular Cyclopropanation Reactions

Siriboe MG, Fasan* R

Bull. Jpn. Soc. Coord. Chem. 2022, 804-13 PDF.

84. Highly Stereoselective and Enantiodivergent Synthesis of Cyclopropylphosphonates with Engineered Carbene Transferases

Ren X, Chandgude AL, Carminati DM, Fasan* R

Chem. Sci. 2022, 13, 8550-8556 PDF.

83. Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization

Iannuzzelliǂ JA, Bacikǂ JP, Moore EJ, Shen Z, Irving EM, Vargas DA, Khare* SD, Ando* N, Fasan* R (ǂ equal contribution)

Biochem. 2022, 61 (11), 1041-1054 PDF.

82. Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N−H Bond Insertion with Acceptor-Acceptor Carbene Donors

Namǂ D, Tinocoǂ A, Shen Z, Adukure RD, Sreenilayam G, Khare* SD, Fasan* R, (ǂ equal contribution)

J. Am. Chem. Soc. 2022, 144 (6), 2590-2602 PDF.

81. Nanoparticle-Mediated Delivery of Micheliolide Analogs to Eliminate Leukemic Stem Cells in the Bone Marrow

Ackun-Farmmer MA, Alwaseem H, Counts M, Bortz A, Giovani S, Frisch* BJ, Fasan* R, Benoit DSW

Adv. Ther. 2022, 5 (1), 2100100 PDF.